Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 28, 2026

Murine Bilateral Renal Lymphadenectomy
06:20

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

120

Lymph node dissection during cytoreductive nephrectomy: a retrospective analysis.

Michael A Feuerstein1, Matthew Kent, Melanie Bernstein

  • 1Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

International Journal of Urology : Official Journal of the Japanese Urological Association
|April 10, 2014
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intensive Care Unit Stay and Mechanical Ventilation Among Adults with Respiratory Syncytial Virus-Related Hospitalization by Age and Comorbidity Status.

Infectious diseases and therapy·2025
Same author

Genomic Basis and Climate Change Vulnerability of Migration Timing in Atlantic Salmon (<i>Salmo salar</i>).

Evolutionary applications·2025
Same author

Coexisting Calcific Aortic Stenosis and Transthyretin Cardiac Amyloidosis: Real-World Evaluation of Clinical Characteristics and Outcomes.

Journal of the American Heart Association·2025
Same author

Response to the Letter to the Editor: "Signs or symptoms of suspected preeclampsia - A retrospective National database study of prevalence, costs, and outcomes".

Pregnancy hypertension·2025
Same author

The National Joint Registry Data Quality Audit of elbow arthroplasty.

The bone & joint journal·2024
Same author

Physiotherapy treatment for reverse total shoulder arthroplasty: Results of a patient-centred rehabilitation guideline using functional and patient-reported outcome measures.

Shoulder & elbow·2024
Same journal

Nocturia Beyond the Bladder: Editorial Comment on Kira et al.'s Nationwide JaCS 2023 Analysis.

International journal of urology : official journal of the Japanese Urological Association·2026
Same journal

Editorial Comment to "Bayesian Multi-Criteria Decision Analysis of Net Clinical Benefit in ARASENS: Overall and Japanese Subgroup Results".

International journal of urology : official journal of the Japanese Urological Association·2026
Same journal

Comparative Analysis of 3-Year Reintervention Rates for Rezum vs. UroLift: A TriNetX Study.

International journal of urology : official journal of the Japanese Urological Association·2026
Same journal

Long-Term Oncologic Outcomes After Laparoscopic Radical Nephroureterectomy: A Contemporary Analysis From a Japanese Multicenter Cohort.

International journal of urology : official journal of the Japanese Urological Association·2026
Same journal

Real-World Outcomes and Prognostic Factors of Immune Checkpoint Inhibitor Rechallenge for Metastatic Renal Cell Carcinoma: A Multicenter Study.

International journal of urology : official journal of the Japanese Urological Association·2026
Same journal

Outcomes of Gemcitabine, Oxaliplatin, and Paclitaxel Salvage Chemotherapy in Japanese Patients With Relapsed or Refractory Germ Cell Tumors.

International journal of urology : official journal of the Japanese Urological Association·2026
See all related articles

Regional lymph node dissection during cytoreductive nephrectomy does not improve survival for metastatic renal cell carcinoma patients. Positive lymph node disease is a poor prognostic indicator, suggesting dissection is best for staging in clinical trials.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Renal Cell Carcinoma Research

Background:

  • Metastatic renal cell carcinoma (mRCC) presents significant treatment challenges.
  • Cytoreductive nephrectomy is a treatment option for some mRCC patients.
  • The role of regional lymph node dissection (LND) in mRCC prognosis remains unclear.

Purpose of the Study:

  • To determine if regional lymph node dissection improves survival in patients with metastatic renal cell carcinoma undergoing cytoreductive nephrectomy.
  • To identify prognostic factors associated with lymph node status in mRCC.

Main Methods:

  • Retrospective review of 258 patients undergoing cytoreductive nephrectomy.
  • Analysis of overall survival using Cox proportional hazards regression.
Keywords:
carcinomacytoreductive nephrectomylymph node dissectionmetastaticrenal cell

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.8K
Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

6.8K

Related Experiment Videos

Last Updated: Feb 28, 2026

Murine Bilateral Renal Lymphadenectomy
06:20

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

120
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.8K
Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

6.8K
  • Logistic regression used to identify risk factors for node-positive disease.
  • Survival analysis stratified by lymph node template and number of nodes removed.

    • Main Results:

    • 177 patients (69%) underwent lymph node dissection; 59 (33%) had positive nodes.
    • No significant difference in 5-year overall survival between patients with and without LND (21% vs. 31%).
    • Positive lymph node status was a significant predictor of poor prognosis (5-year survival 9% vs. 27% for negative nodes).
    • Lymphadenopathy was a strong predictor of node-positive disease in patients undergoing LND.

    Conclusions:

    • Regional lymph node dissection during cytoreductive nephrectomy does not confer a survival benefit for mRCC patients.
    • Lymph node-positive disease is a critical negative prognostic factor.
    • Lymph node dissection may serve as a valuable staging procedure within clinical trials for mRCC.