Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pore Transport and Ion-Pair Transport

Pore Transport and Ion-Pair Transport

Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...

The Electrical Double Layer

The Electrical Double Layer

In the region where two bulk phases meet, an intricate electric charge distribution arises due to charge transfer, ion adsorption, molecular orientation, and charge distortion. This complex distribution is commonly referred to as the electrical double layer.When a solid electrode interfaces with ions in an electrolyte solution, the speed of electron transfer dictates the rates of oxidation and reduction. The electrode acquires a charge through the escape of atoms into the solution as cations or...

Electrophoresis: Overview

Electrophoresis: Overview

Electrophoresis is a powerful analytical separation technique that relies on the differential migration of charged species when subjected to an electric field. The core strength of electrophoresis lies in its ability to separate high-molecular-weight species in complex mixtures. It has found widespread use in biochemistry, molecular biology, and analytical chemistry, allowing the separation of compounds like amino acids, nucleotides, carbohydrates, and proteins with excellent resolution.
There...

Electrochemical Gradient and Channel Proteins: An Overview

Electrochemical Gradient and Channel Proteins: An Overview

An electrochemical gradient is a fundamental concept in biology and chemistry. It regulates the movement of ions across cell membranes. This movement is influenced by two factors:
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell. This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to...

Electrochemical Systems

Electrochemical Systems

Electrochemical systems provide a fascinating insight into the dynamic interplay of charged species within various phases. One notable example is the interaction between a membrane permeable to K⁺ ions but not to Cl⁻ ions, separating an aqueous KCl solution from pure water. As K⁺ ions diffuse through the membrane, they generate net charges on each phase, leading to a potential difference between them.Similarly, when a piece of Zn is immersed in an aqueous ZnSO₄ solution,...

Potentiometry: Membrane Electrodes

Potentiometry: Membrane Electrodes

Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evolutionary and Structural Insights into Proline Metabolism Genes Associated with Salt Resilience in Mango.

Biochemical genetics·2026

Same author

Metabolite-Mediated Antioxidant-Rich Bacterial Isolates for the Control of Anthracnose Disease and Enhancement of the Post-Harvest Shelf Life of Mango (<i>Mangifera indica</i> L.).

Plants (Basel, Switzerland)·2026

Same author

Harnessing the Potential of a Secondary Metabolite-Based Formulation for the Post-Harvest Disease Management and Shelf Life Extension of Banana.

Metabolites·2026

Same author

Exploring the antifungal potential of novel Bacillus siamensis RBN19 against Bipolaris oryzae infecting rice: in vitro and in silico studies.

Microbial pathogenesis·2025

Same author

Synthesis of diversely substituted quinazoline-2,4(1<i>H</i>,3<i>H</i>)-diones by cyclization of <i>tert</i>-butyl (2-cyanoaryl)carbamates.

Organic & biomolecular chemistry·2024

Same author

Fiber Optic Sensor Coated with Multiple Layers of Hexagonal Boron Nitride Nanosheets (BNNS) for the Detection of Volatile Organic Compounds.

ACS applied materials & interfaces·2024

Search research articles

Related Experiment Video

Updated: May 1, 2026

Monitoring Protein Adsorption with Solid-state Nanopores

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

Effect of charge patterns along a solid-state nanopore on polyelectrolyte translocation.

H H Katkar¹, M Muthukumar¹

¹Department of Polymer Science and Engineering, Room A212, University of Massachusetts, Amherst, Massachusetts 01003, USA.

The Journal of Chemical Physics

|April 10, 2014

Summary

We studied how nanopore charge patterns affect flexible polyelectrolyte translocation. An optimal charge pattern significantly delays translocation, especially during pore ejection, offering insights into nanopore-based sensing technologies.

More Related Videos

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example

Published on: October 26, 2016

Related Experiment Videos

Last Updated: May 1, 2026

Monitoring Protein Adsorption with Solid-state Nanopores

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example

Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example

Published on: October 26, 2016

Area of Science:

Nanotechnology
Polymer Physics
Computational Biophysics

Background:

Understanding polyelectrolyte behavior in confined geometries is crucial for nanopore sensing.
The dynamics of flexible polymers translocating through nanopores are influenced by various factors, including pore geometry and applied fields.
Controlling translocation dynamics is key to improving resolution and functionality in nanopore applications.

Purpose of the Study:

To investigate the impact of longitudinal charge patterns within a nanopore on the translocation dynamics of a flexible polyelectrolyte.
To determine if specific charge distributions can modulate translocation times and reveal underlying mechanisms.
To compare simulation results with theoretical predictions based on established physical formalisms.

Main Methods:

Three-dimensional Langevin dynamics simulations were employed to model the translocation process.
A uniformly charged flexible polyelectrolyte was simulated translocating through a solid-state nanopore under a uniform external electric field.
The pore's total charge was kept constant, while its distribution was varied using alternating charged and uncharged sections of differing lengths.

Main Results:

The longest average translocation times were observed for a specific, optimum section length in the charge pattern.
A significant delay in translocation was identified during the pore ejection stage for this optimum pattern.
The determined optimum section length was found to be independent of the polyelectrolyte and pore lengths within the studied range.

Conclusions:

Nanopore charge patterning offers a viable strategy to control and potentially optimize polyelectrolyte translocation dynamics.
The observed delay during pore ejection suggests specific interactions governed by the charge pattern.
A Fokker-Planck formalism-based theory successfully described the simulation trends, validating the theoretical framework and providing quantitative agreement.