Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

12.9K
For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
12.9K
Sanger Sequencing01:57

Sanger Sequencing

800.8K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
800.8K
The DNA Helix01:16

The DNA Helix

129.4K
Overview
129.4K
Next-generation Sequencing03:00

Next-generation Sequencing

87.9K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
87.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

A Point-of-Care System for the Quantification of Small-Molecule Drugs in Blood.

ACS sensors·2026
Same author

Quantum yield standards for the photosensitized production of singlet oxygen in water.

Physical chemistry chemical physics : PCCP·2026
Same author

Biosynthesis, Structure, and Antibiotic Properties of Gelatinamin A, a Triculamin-Like Lasso Peptide.

Chembiochem : a European journal of chemical biology·2026
Same author

Hypoxia-induced production of the cyclolipodepsipeptide BE-43547 by <i>Micromonospora</i> sp. RV43.

Microbiology (Reading, England)·2026
Same author

Applications of 2-(Bromoalkyl)Benzaldehydes in Bioconjugation.

Bioconjugate chemistry·2026

Related Experiment Video

Updated: May 1, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

12.7K

Singlet oxygen in DNA nanotechnology.

Thomas Tørring1, Sarah Helmig, Peter R Ogilby

  • 1Center for DNA Nanotechnology (CDNA) at the Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University , DK-8000 Aarhus C, Denmark.

Accounts of Chemical Research
|April 10, 2014
PubMed
Summary

DNA nanostructures precisely control singlet oxygen ((1)O2) generation and reactions. This advancement enables targeted therapies and novel synthetic applications by regulating photosensitizer behavior.

More Related Videos

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
08:00

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

Published on: October 25, 2017

6.6K
Author Spotlight: Advancements in DNA Nanosensors &#8211; Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

1.8K

Related Experiment Videos

Last Updated: May 1, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

12.7K
DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
08:00

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

Published on: October 25, 2017

6.6K
Author Spotlight: Advancements in DNA Nanosensors &#8211; Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

1.8K

Area of Science:

  • Biochemistry
  • Nanotechnology
  • Organic Chemistry

Background:

  • Singlet oxygen ((1)O2) is a reactive molecule with applications in organic synthesis and cancer therapy.
  • Controlled generation of (1)O2 is challenging due to oxygen's abundance.
  • DNA nanostructures offer precise control over molecular interactions at the nanoscale.

Purpose of the Study:

  • To demonstrate how DNA nanostructures can regulate singlet oxygen production.
  • To explore the use of DNA structures in controlling photosensitizer and quencher molecules.
  • To showcase DNA-based systems for switching (1)O2 generation ON/OFF and utilizing (1)O2 in DNA-based systems.

Main Methods:

  • Utilizing DNA nanostructures to control the proximity of photosensitizers and quencher molecules.
  • Developing DNA systems for tunable (1)O2 production (sequence and pH dependent).
  • Employing (1)O2 to activate/deactivate DNA systems via reactions with cleavable linkers.

Main Results:

  • DNA structures effectively regulate (1)O2 production by controlling photosensitizer-quencher interactions.
  • DNA-based systems demonstrated controllable ON/OFF switching of (1)O2 generation.
  • Singlet oxygen was successfully used to release blocked oligonucleotides and modify DNA origami structures.

Conclusions:

  • DNA nanostructures provide a powerful platform for precise control over singlet oxygen generation and reactivity.
  • These findings open avenues for advanced applications in targeted therapies, organic synthesis, and nanoscale molecular devices.
  • The study highlights the versatility of DNA nanotechnology in manipulating reactive oxygen species for complex chemical and biological processes.