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Published on: October 6, 2017
Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system
Andrew D Randall1, Mai Kurihara, Nicholas J Brandon
1School of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol, UK; Institute of Biomedical and Clinical Sciences, University of Exeter, The Hatherley Building, Prince of Wales Road, Exeter, EX4 4PS, UK.
Abstract:
The disrupted in schizophrenia 1 (DISC1) gene is found at the breakpoint of an inherited chromosomal translocation, and segregates with major mental illnesses. Its potential role in central nervous system (CNS) malfunction has triggered intensive investigation of the biological roles played by DISC1, with the hope that this may shed new light on the pathobiology of psychiatric disease. Such work has ranged from investigations of animal behavior to detailed molecular-level analysis of the assemblies that DISC1 forms with other proteins. Here, we discuss the evidence for a role of DISC1 in synaptic function in the mammalian CNS.
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