Related Experiment Video
Updated: May 1, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.5K
Maximal testosterone suppression in prostate cancer--free vs total testosterone
Kyle O Rove1, E David Crawford1, Massimo Perachino2
1Division of Urology, University of Colorado, Anschutz Medical Campus, Aurora, CO.
Urology
|April 10, 2014
Summary
Free testosterone may be a better indicator of prostate cancer tissue androgen levels than total testosterone. Further research is needed to explore free testosterone
Area of Science:
- Oncology
- Endocrinology
Background:
- Testosterone is a key target in advanced prostate cancer treatment.
- The role of free testosterone in prostate cancer outcomes is under-researched.
Purpose of the Study:
- To review current knowledge on total and free testosterone in prostate cancer.
- To discuss the free hormone hypothesis.
- To identify future therapeutic avenues.
Main Methods:
- A consensus of prostate cancer experts was convened in 2013.
- Review of existing literature and expert discussion.
Main Results:
- Free testosterone may more accurately reflect prostate cancer tissue androgen levels compared to serum total testosterone.
- The free hormone hypothesis warrants further investigation.
Conclusions:
- Free testosterone requires additional research to understand its relationship with clinical outcomes in prostate cancer.
- Exploring free testosterone could lead to novel therapeutic strategies.
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