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Risk of hip fracture associated with untreated and treated chronic hepatitis B virus infection

Dana D Byrne1, Craig W Newcomb2, Dean M Carbonari3

  • 1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Journal of Hepatology
|April 10, 2014
PubMed

Insights

Chronic hepatitis B (CHB) infection increases hip fracture risk, particularly in Black patients. Untreated CHB infection poses a significant risk for hip fractures in Black individuals compared to those without CHB.

Area of Science:

  • Hepatology
  • Bone Metabolism
  • Epidemiology

Background:

  • Chronic hepatitis B (CHB) is linked to reduced bone density.
  • The association between CHB infection and fracture risk remains unclear.
  • This study investigates hip fracture risk in CHB patients.

Purpose of the Study:

  • To determine if untreated or treated CHB patients have an increased risk of hip fracture.
  • Comparison is made against uninfected individuals.

Main Methods:

  • A cohort study of 18,796 untreated CHB, 7,777 treated CHB, and 979,751 uninfected individuals was conducted.
  • Data was sourced from U.S. Medicaid populations (1999-2007).
  • Propensity score matching and Cox regression were used to analyze hip fracture risk.

Main Results:

  • Untreated Black patients with CHB had a significantly higher hip fracture rate (HR, 2.55) than uninfected Black individuals.
  • Increased, though not statistically significant, hip fracture hazards were observed in untreated White and Hispanic CHB patients, and treated Black and White CHB patients.
  • The study identified a higher risk of hip fracture in untreated CHB-infected Black patients.

Conclusions:

  • Untreated CHB infection is associated with a higher risk of hip fracture among Black patients within U.S. Medicaid enrollees.
  • Further research may be needed to clarify risks in other racial groups and treated CHB patients.
Abstract

Keywords:
BoneFractureHepatitis B

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