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Related Experiment Video

Updated: May 1, 2026

Deferred Growth Inhibition Assay to Quantify the Effect of Bacteria-derived Antimicrobials on Competition

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Triclosan promotes Staphylococcus aureus nasal colonization.

Adnan K Syed, Sudeshna Ghosh, Nancy G Love

|April 10, 2014

Summary

The biocide triclosan, found in nasal secretions, promotes Staphylococcus aureus binding to surfaces and increases nasal colonization. This highlights unintended consequences of triclosan use on human health.

Area of Science:

Microbiology
Environmental Health
Toxicology

Background:

Triclosan is a widely used biocide in personal care products, leading to environmental and human fluid contamination.
Staphylococcus aureus colonization is a significant risk factor for various infections.

Purpose of the Study:

To investigate the presence of triclosan in nasal secretions and its correlation with Staphylococcus aureus colonization.
To determine the effect of triclosan on S. aureus binding to host proteins and surfaces.
To assess the impact of triclosan exposure on S. aureus nasal colonization susceptibility in a rat model.

Main Methods:

Detection of triclosan in human nasal secretions.
In vitro assays measuring S. aureus binding to host proteins (collagen, fibronectin, keratin) and surfaces (plastic, glass) with and without triclosan.

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A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent

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Assessment of S. aureus nasal colonization in rats following triclosan exposure.

Main Results:

Triclosan was frequently detected in nasal secretions of healthy adults, correlating positively with S. aureus colonization.
Triclosan enhanced S. aureus adherence to host proteins and inanimate surfaces.
Rats exposed to triclosan exhibited increased susceptibility to S. aureus nasal colonization.

Conclusions:

Triclosan presence in nasal secretions is linked to increased S. aureus colonization.
Triclosan alters S. aureus surface binding properties, potentially facilitating colonization.
These findings reveal an unintended consequence of triclosan use, impacting S. aureus colonization and infection risk.