Related Experiment Video
Updated: May 1, 2026
Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion
Published on: May 4, 2011
Emotional and neutral verbal memory impairment in Multiple Sclerosis
Pietro Iaffaldano1, Rosa Gemma Viterbo1, Benedetta Goretti2
1Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
Background:
A defective emotional enhancement of verbal memory (VM) performances has been reported in different neurological diseases.
Objectives:
To assess the emotional enhancement of VM in 22 Clinically Isolated Syndrome (CIS) suggestive of Multiple Sclerosis (MS) and 49 Relapsing (RR) MS patients in comparison to 32 Healthy Controls (HC).
Methods:
Immediate and delayed recall of VM was assessed using the Selective Reminding Test (SRT). A list of 12 emotionally significant words was used to evaluate the Emotional (E) variants of the SRT. Depressive symptoms were assessed by the Beck Depression Inventory.
Results:
The prevalence of depression did not differ between RRMS and CIS patients. Both patient groups showed poorer (p<0.01) VM performances in comparison to HC in all the SRT tasks, but no difference was found between the two patient groups. Emotionally salient words were more (p<0.0001) recalled than neutral words in HC and CIS, but not in RRMS patients, while performing the immediate recall tasks. Delayed recall was not affected by emotional stimuli in both CIS and RR MS groups. The presence of depressive symptoms did not influence the VM performances.
Conclusions:
Our results demonstrate a defective emotional enhancement of VM in definite MS and, although to a lesser extent, in CIS patients.
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