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Related Experiment Video

Updated: May 1, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Pathology consultation on electronic crossmatch.

Marshall A Mazepa¹, Jay S Raval, Yara A Park

¹101 Manning Dr, Memorial Hospital, 1021 East Wing, Campus Box 7525, Chapel Hill, NC 27599; mmazepa@unch.unc.edu.

American Journal of Clinical Pathology

|April 10, 2014

Summary

This summary is machine-generated.

Electronic crossmatch (EXM) offers a reliable alternative to traditional serologic testing for patients without clinically significant antibodies. This method enhances compatibility testing by reducing errors associated with immediate-spin crossmatch.

Keywords:

Crossmatch EXM Electronic crossmatch

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Area of Science:

Transfusion Medicine
Immunology
Clinical Pathology

Background:

The full crossmatch is a critical final step in blood compatibility testing, ensuring ABO compatibility and detecting unexpected red blood cell (RBC) antibodies.
Electronic crossmatch (EXM) has emerged as a modern alternative to traditional serologic methods.

Observation:

EXM relies on sensitive screening assays, necessitating thorough investigation of clinically significant antibodies.
Immediate-spin crossmatch (IS XM) is susceptible to serologic interference errors.
EXM's accuracy depends on accurate sample labeling, data entry, and robust informatics systems.

Findings:

EXM is a viable alternative to serologic testing for patients lacking clinically significant antibodies.
Compared to IS XM, EXM offers a potentially more accurate compatibility assessment when implemented correctly.

Implications:

The adoption of EXM can streamline compatibility testing processes in blood banking.
Understanding the strengths and weaknesses of EXM is crucial for its safe and effective implementation.
Further research into optimizing EXM protocols can enhance patient safety in transfusion medicine.