Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gastrointestinal Motility Disorders

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...

Pyloric Obstruction

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...

Esophageal Achalasia

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide...

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...

Gastric Motility

Gastric Motility

Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Concurrent Presentation of Idiopathic Intracranial Hypertension and Bilateral Optic Perineuritis in a Young Boy: A Rare Clinical Entity.

Cureus·2026

Same author

The role of metformin in pediatric metabolic dysfunction-associated steatotic liver disease.

European journal of pediatrics·2025

Same author

Eslicarbazepine Overdosing in a Teenager: Case Description and Management.

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG·2025

Same author

Refeeding syndrome and rumination in a pediatric patient: A case report reflecting an underdiagnosed pediatric emergency.

JPGN reports·2025

Same author

Charting the Path: Psychological Factors and Diet Adherence in Adolescents With Celiac Disease.

Cureus·2024

Same author

A 17-month-old girl with fetal valproate syndrome and ocular coloboma.

Clinical dysmorphology·2024

Search research articles

Related Experiment Video

Updated: May 1, 2026

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

Gastroparesis in children.

Efstratios Saliakellis¹, Maria Fotoulaki²

¹Department of Pediatric Gastroenterology, Academy of Pediatric Gastroenterology, Great Ormond Street Hospital, NHS Foundation Trust, London, UK (Efstratios Saliakellis).

Annals of Gastroenterology

|April 10, 2014

Summary

This summary is machine-generated.

Gastroparesis, a condition of delayed gastric emptying, presents diagnostic and treatment challenges in children. Evidence-based protocols are needed for optimal management and outcomes.

Keywords:

Gastroparesis children gastric emptying gastric motility disorders

More Related Videos

Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test

Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test

Published on: March 23, 2013

Fabrication and Implantation of Miniature Dual-element Strain Gages for Measuring In Vivo Gastrointestinal Contractions in Rodents.

Fabrication and Implantation of Miniature Dual-element Strain Gages for Measuring In Vivo Gastrointestinal Contractions in Rodents.

Published on: September 18, 2014

Related Experiment Videos

Last Updated: May 1, 2026

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test

Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test

Published on: March 23, 2013

Fabrication and Implantation of Miniature Dual-element Strain Gages for Measuring In Vivo Gastrointestinal Contractions in Rodents.

Fabrication and Implantation of Miniature Dual-element Strain Gages for Measuring In Vivo Gastrointestinal Contractions in Rodents.

Published on: September 18, 2014

Area of Science:

Pediatric Gastroenterology
Gastrointestinal Motility Disorders

Background:

Gastroparesis is defined by delayed gastric emptying without mechanical obstruction.
Prevalence in children is unknown, with symptoms including nausea, vomiting, and failure to thrive.
Diagnosis relies on symptoms and confirmed delayed gastric emptying, with scintigraphy as the gold standard.

Approach:

A comprehensive literature search was conducted using major medical databases.
Included original articles and reviews focusing on pediatric gastroparesis diagnosis, treatment, and outcomes.
Synthesized evidence to provide an overview of current knowledge and future directions.

Key Points:

Gastric emptying scintigraphy is the gold standard for diagnosis.
Treatment involves dietary changes, medications (prokinetics, antiemetics), and potentially surgery (gastric pacemaker).
Nutritional support via enteral feeding or parenteral nutrition may be necessary.

Conclusions:

Pediatric gastroparesis diagnosis and treatment are complex.
Standardized protocols for gastric emptying evaluation and stepwise management are crucial.
Optimizing management strategies is essential for improving patient outcomes.