Related Experiment Video
Updated: May 1, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
Patients with refractory gastroesophageal reflux disease: diagnostic tools
Georgios P Karamanolis1, Daniel Sifrim2
1Gastroenterology Unit, 2 Surgical Department, Aretaieion Hospital, Athens Medical School, Athens, Greece (Georgios P. Karamanolis.
Abstract:
Patients with refractory to proton pump inhibitors (PPIs) gastroesophageal reflux disease (GERD) symptoms are approximately 40% and represent a very common problem in clinical practice. Many of these patients do not have GERD, but suffer from functional heartburn or hypersensitive esophagus. After thorough clinical evaluation and failure of escalation of PPI dose, diagnostic investigations include endoscopy, esophageal manometry, pH testing, esophageal Bilitec and esophageal impedance with pH monitoring.
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