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Platelet IgG antibodies are significantly increased in chronic liver disease

Dimitrios Christodoulou1, Konstantinos Katsanos1, Eleftheria Zervou2

  • 11 Department of Internal Medicine and Hepato-Gastroenterology Unit, School of Medicine, University of Ioannina, Greece (Dimitrios Christodoulou, Konstantinos Katsanos, Vasileios Theopistos, Athanasios Papathanasopoulos, Leonidas Christou, Epameinondas V. Tsianos).

Annals of Gastroenterology
|April 10, 2014
PubMed

Insights

Patients with chronic liver disease (CLD) frequently have IgG antiplatelet (anti-P) antibodies. This study found a significantly higher prevalence of these antibodies in CLD patients compared to healthy individuals.

Area of Science:

  • Immunology
  • Hepatology
  • Internal Medicine

Background:

  • Chronic liver disease (CLD) encompasses various etiologies, including viral hepatitis and alcohol-related liver damage.
  • Platelet dysfunction and immune dysregulation are observed in CLD patients.
  • The role of antiplatelet (anti-P) IgG antibodies in CLD pathogenesis requires further investigation.

Purpose of the Study:

  • To investigate the prevalence of IgG antiplatelet (anti-P) antibodies in patients diagnosed with chronic liver disease (CLD).
  • To compare the presence of anti-P antibodies in CLD patients with that in healthy controls.
  • To assess the association of anti-P antibodies with different etiologies of CLD and disease severity (cirrhosis).

Main Methods:

  • A cohort of 156 patients with diverse CLD etiologies (chronic hepatitis B, chronic hepatitis C, alcoholic liver disease, primary biliary cirrhosis) was studied.
  • The presence of anti-P antibodies was assessed in CLD patients and 240 healthy blood donors.
  • Statistical analysis was performed to compare antibody prevalence between groups and correlate with clinical factors.

Main Results:

  • Anti-P antibodies were detected in 36.5% of CLD patients versus 2.9% of controls (P=0.0001).
  • Prevalence varied by etiology: 72.7% in primary biliary cirrhosis, 47.8% in alcoholic liver disease, 35.4% in chronic hepatitis B, and 26.3% in chronic hepatitis C.
  • Antibody prevalence was significantly higher in cirrhotic patients (53.0%) than non-cirrhotic patients (26.4%, P=0.0018).

Conclusions:

  • A high prevalence of IgG anti-P antibodies exists in patients with chronic liver disease.
  • These antibodies are significantly more common in CLD patients than in healthy individuals.
  • The findings suggest a potential role for anti-P antibodies in the immune response associated with chronic liver disease.
Abstract

Keywords:
antiplatelet antibodieschronic hepatitischronic liver diseasecirrhosisthrombocytopenia

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