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Adherence to growth hormone therapy: a practical approach

M Bozzola1, S Pagani, L Iughetti

  • 1Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Hormone Research in Paediatrics
|April 10, 2014
PubMed

Insights

Early detection of poor adherence to growth hormone (GH) therapy is vital for growth hormone-deficient (GHD) patients. Regular patient interviews are essential for improving adherence and ensuring effective communication.

Area of Science:

  • Pediatric Endocrinology
  • Growth Hormone Therapy
  • Patient Adherence

Background:

  • Growth hormone (GH) deficiency (GHD) requires timely intervention to ensure normal final height.
  • Monitoring adherence to GH therapy is critical for treatment success in children.

Purpose of the Study:

  • To investigate the challenges in detecting and managing poor adherence to GH therapy in GHD patients.
  • To identify strategies for improving patient and parent communication regarding GH treatment.

Main Methods:

  • Study included 106 children with GHD (short stature, delayed bone age).
  • GH therapy administered via daily subcutaneous injections.
  • Adherence assessed through clinical monitoring and patient reporting.

Main Results:

  • Poor adherence was suspected in several patients, with 4 cases clearly demonstrating reduced height velocity despite treatment.
  • Confirmed non-adherence correlated with poor therapeutic response.
  • Clinical and anthropometric data indicated the impact of non-adherence.

Conclusions:

  • Regular, non-aggressive interviews with patients and parents are crucial for effective communication.
  • Proactive communication strategies can help improve adherence to GH therapy in GHD patients.
Abstract

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