Related Experiment Video

Updated: May 1, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

19.1K

Effect of vitamin D therapy in addition to amitriptyline on migraine attacks in pediatric patients

A Cayir1, M I Turan2, H Tan3

  • 1Department of Pediatric Endocrinology, Regional Training and Research Hospital, Erzurum, Turkey.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|April 10, 2014
PubMed

Insights

This study found that vitamin D supplementation, alongside amitriptyline, significantly reduced migraine attacks in children. Even with normal vitamin D levels, adding it to treatment improved outcomes for pediatric migraine patients.

Area of Science:

  • Pediatric Neurology
  • Nutritional Neuroscience
  • Migraine Pathophysiology

Background:

  • Migraine is a prevalent neurological disorder in children.
  • Vitamin D deficiency is common and may influence neurological conditions.
  • Current treatments for pediatric migraine have limitations.

Purpose of the Study:

  • To evaluate the efficacy of supplementary vitamin D in pediatric migraine patients receiving amitriptyline.
  • To assess the impact of varying vitamin D dosages based on baseline 25-hydroxyvitamin D [25(OH)D] levels.

Main Methods:

  • Fifty-three children (8-16 years) with migraine were enrolled and categorized into four groups based on 25(OH)D levels.
  • Groups received either amitriptyline alone or amitriptyline plus varying daily doses of vitamin D (400-5000 IU/day) for 6 months.
  • Migraine attack frequency and biochemical markers (calcium, phosphorus, etc.) were monitored pre- and post-treatment.

Main Results:

  • All vitamin D supplemented groups showed a statistically significant reduction in migraine attacks compared to baseline.
  • Groups receiving vitamin D alongside amitriptyline experienced fewer migraine attacks (1.15-2.14 attacks) versus amitriptyline alone (3 attacks).
  • No significant changes were observed in calcium, phosphorus, alkaline phosphatase, or parathormone levels across groups.

Conclusions:

  • Vitamin D supplementation, when added to amitriptyline, effectively reduces migraine attack frequency in pediatric patients.
  • The study suggests a potential therapeutic role for vitamin D in managing pediatric migraine, irrespective of baseline vitamin D status.
  • Further research is warranted to optimize vitamin D dosing strategies for migraine management in children.

More Related Videos

Clinical Efficacy of an Innovative Multidimensional Traction Therapy in Moderate Adolescent Idiopathic Scoliosis07:12

Clinical Efficacy of an Innovative Multidimensional Traction Therapy in Moderate Adolescent Idiopathic Scoliosis

Published on: February 10, 2026

292
Investigating Migraine-Like Behavior Using Light Aversion in Mice05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

3.6K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
408
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
967
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
410