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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

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Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
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Disorders of Erythrocytes01:27

Disorders of Erythrocytes

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Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
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Leitlinie der Gesellschaft für Thrombose- und Hämostaseforschung (GTH) zur Struktur- und Prozessqualität von Hämophilie-Zentren.

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Related Experiment Video

Updated: May 1, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
08:01

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

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[Acquired bleeding disorders - diagnostic approach].

R Klamroth1

  • 1Klinik für Innere Medizin, Angiologie und Hämostaseologie/Hämophiliezentrum, Vivantes - Klinikum im Friedrichshain, Landsberger Allee 49, 10249, Berlin, Deutschland, robert.klamroth@vivantes.de.

Der Internist
|April 10, 2014
PubMed
Summary

Diagnosing acquired bleeding disorders requires a thorough patient history and specific coagulation tests. These steps are crucial for identifying the cause and ensuring correct diagnosis in internal medicine.

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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
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Last Updated: May 1, 2026

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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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Area of Science:

  • Internal Medicine
  • Hematology
  • Clinical Diagnostics

Context:

  • Acquired bleeding disorders present diagnostic challenges in internal medicine.
  • Effective diagnostic workup is essential for patient management.

Purpose:

  • To outline the necessary diagnostic workup for patients with acquired bleeding disorders.
  • To identify useful coagulation tests for diagnosing these conditions.

Summary:

  • A detailed bleeding history and physical examination are the initial steps.
  • Global coagulation assays like Prothrombin Time (PT) and Partial Thromboplastin Time (PTT), along with platelet count and function tests, provide initial insights.
  • Specialized coagulation tests are vital for pinpointing the exact cause of acquired bleeding disorders.

Impact:

  • Facilitates accurate diagnosis of acquired bleeding disorders.
  • Guides clinicians in selecting appropriate diagnostic tests.
  • Improves patient outcomes through timely and precise diagnosis.