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Updated: Aug 12, 2026
11:29
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
5'-nucleotidase activity in prostatic carcinoma and benign prostatic hyperplasia
R R Rackley1, T J Lewis, E M Preston
1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106.
Cancer Research
|July 1, 1989
Summary
5'-nucleotidase activity is significantly lower in prostate cancer tissues compared to benign hyperplasia. This enzyme
Area of Science:
- Biochemistry
- Oncology
- Histopathology
Background:
- Previous studies indicated altered 5'-nucleotidase activity in neoplastic conditions.
- 5'-nucleotidase is an enzyme involved in nucleotide metabolism.
Purpose of the Study:
- To investigate 5'-nucleotidase activity in human hyperplastic prostates and prostatic carcinomas.
- To correlate enzyme activity with tumor differentiation and patient survival.
Main Methods:
- Histochemical examination of 5'-nucleotidase activity in tissue sections.
- Biochemical quantification of 5'-nucleotidase activity in prostate tissue extracts.
- Statistical analysis correlating enzyme activity with histological grade and patient survival.
Main Results:
- Prostate carcinomas exhibited significantly lower 5'-nucleotidase activity per mg protein than benign prostatic hyperplasia.
- Lower enzyme activity correlated with poor histological differentiation (Gleason's grade).
- Enzyme activity, adjusted for age and grade, positively correlated with patient survival.
Conclusions:
- Prostatic epithelium expresses 5'-nucleotidase.
- Decreased 5'-nucleotidase activity is a marker for prostate cancer and a predictor of survival.
- Further research is needed to understand the role of 5'-nucleotidase in prostate health and disease.
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