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Complication of Invasive Molar Pregnancy with Clostridium perfringens Sepsis

Sanmeet Singh1, Kunal Angra1, Bonnie Davis2

  • 1Howard University College of Medicine, Washington, DC 20059, USA.

Case Reports in Obstetrics and Gynecology
|April 10, 2014
PubMed

Clostridium perfringens (CP) is an anaerobic, Gram-positive bacillus associated with malignant diseases and near-term pregnancies. The necrotic tissue that results from these disease processes fuels the proliferation of CP, leading to gas gangrene and subsequently sepsis. Herein, we report a case of a 41-year-old female patient with a history of invasive molar pregnancy that was further complicated with a CP infection. Although past research has shown a link between Clostridium infection and choriocarcinoma (Chern-Horng and Hsieh, 1999), no previous cases of CP infection have been associated with invasive molar pregnancy. We also report complete resolution of the CP sepsis and its associated symptoms following the hysterectomy.

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