Therapeutic potential of chinese herbal medicines in alcoholic liver disease

Alcoholic liver disease (ALD) is a complex chronic disease and is associated with a spectrum of liver injury ranging from steatosis and steatohepatitis to fibrosis and cirrhosis. Since effective therapies for ALD are still limited, Chinese herbal medicine is thought to be an important and alternative approach. This review focuses on the current scientific evidence of ALD by ten Chinese Materia Medica ( zhōng yào), including Salviae Miltiorrhizae Radix ( dān shēn), Notoginseng Radix ( sān qī), Lycii Fructus ( gǒu qǐ zǐ), Cnidii Fructus ( shé chuáng zǐ), Gentianae Radix ( lóng dǎn), Puerariae Radix ( gé gēn), Puerariae Flos ( gé huā), Magnoliae Officinalis Cortex ( hòu pò), Platycodonis Radix ( jié gěng), and Trigonellae Semen ( hú lú bā). Potential mechanisms of these herbal medicines in ALD are involved in amelioration of enhanced inflammation, reduction of hepatic oxidative stress and lipogenesis, and enhancement of intestinal permeability in alcohol-induced liver injury models in vitro and in vivo. Accordingly, the evidenced therapeutic potential suggests that these herbs are promising candidates for prevention and development of new drugs for ALD in the future.