Related Experiment Video

Updated: May 1, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

19.8K

Plasma natriuretic peptides in children and adolescents with obstructive sleep apnea and their changes following

Albert Martin Li1, Chun Ting Au1, Jodie Y Zhu1

  • 1Department of Paediatrics, The Chinese University of Hong Kong , Hong Kong , China.

Frontiers in Pediatrics
|April 10, 2014
PubMed

Insights

Obesity, not obstructive sleep apnea (OSA), significantly impacts natriuretic peptide (NP) levels in children and adolescents. Treatment for OSA did not alter these peptide concentrations, highlighting BMI as the primary factor.

Area of Science:

  • Pediatric Endocrinology
  • Sleep Medicine
  • Cardiovascular Physiology

Background:

  • Obstructive sleep apnea (OSA) is increasingly recognized in children and adolescents.
  • Natriuretic peptides (NP) are biomarkers associated with cardiovascular strain.
  • The relationship between obesity, OSA, and NP levels in pediatric populations requires further elucidation.

Purpose of the Study:

  • To investigate circulating natriuretic peptide (NP) concentrations in obese and non-obese children and adolescents with and without obstructive sleep apnea (OSA).
  • To evaluate the effect of OSA treatment on NP levels in this cohort.

Main Methods:

  • Recruitment of children with habitual snoring and OSA symptoms.
  • Diagnosis of OSA via overnight polysomnography (PSG) with an apnea-hypopnea index (OAHI) ≥1/h.
  • Measurement of fasting serum atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) post-PSG.

Main Results:

  • One hundred fourteen children (median age 10.8 years) were analyzed; 68 had OSA.
  • No significant difference in NP levels was observed between subjects with and without OSA, irrespective of obesity status.
  • Body mass index (BMI) z-score emerged as the sole independent predictor of NP concentrations.
  • Post-treatment assessment in 15 children with moderate-to-severe OSA showed no significant changes in ANP or BNP levels.

Conclusions:

  • Body mass index (BMI) is the primary determinant of natriuretic peptide (NP) levels in school-aged children and adolescents.
  • Obstructive sleep apnea (OSA) itself does not appear to be a significant independent factor influencing NP levels in this age group.
  • Current OSA treatment strategies may not substantially alter NP levels in pediatric patients.
Abstract

Keywords:
adenotonsillectomynatriuretic peptidesobesityobstructive sleep apnea

More Related Videos

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

847
Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

1.6K

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
914
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
632
Hormonal Regulation of Blood Pressure01:17

Hormonal Regulation of Blood Pressure

Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
7.8K
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
931
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.9K
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
615