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Nanoparticle-mediated pulmonary drug delivery: a review
Mukta Paranjpe1, Christel C Müller-Goymann2
1Institute for Pharmaceutical Technology, TU Braunschweig, Mendelssohnstr. 1, 38106 Braunschweig, Germany. mukta.paranjpe@tu-bs.de.
International Journal of Molecular Sciences
|April 11, 2014
Summary
Colloidal drug delivery systems offer a promising noninvasive pulmonary route for treating lung diseases. Maintaining critical physicochemical parameters is key for successful nebulization and targeted drug delivery.
Area of Science:
- Pharmaceutical Sciences
- Nanotechnology
- Respiratory Medicine
Background:
- Colloidal drug delivery systems are explored for various administration routes.
- Solid lipid nanoparticles, polymeric nanoparticles, and liposomes are established for lung disease treatment.
- The pulmonary route is ideal for local and systemic drug delivery, offering rapid absorption and bypassing first-pass metabolism.
Purpose of the Study:
- To review the current status of colloidal systems for lung disorder treatment.
- To discuss characterization methods for these systems.
- To explore in vitro, ex vivo, and in vivo models for evaluating colloidal systems.
Main Methods:
- Literature review of colloidal systems for pulmonary drug delivery.
- Analysis of characterization techniques for inhaled colloidal formulations.
- Discussion of cell-based models for efficacy and safety testing.
Main Results:
- Colloidal systems show potential for targeted pulmonary drug delivery via inhalation.
- Physicochemical parameter control is crucial for nebulization efficacy.
- Surfactant-associated proteins can enhance formulation performance.
Conclusions:
- Colloidal systems are a viable strategy for pulmonary drug delivery.
- Further research is needed on optimizing formulations and testing models for inhalation.
- Successful development requires careful consideration of physicochemical properties and biological evaluation.
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