Uterine leiomyosarcoma metastasizing to the heart

Area of Science:

• Gynecologic Oncology
• Cardiovascular Pathology
• Medical Oncology

Background:

• Uterine leiomyosarcoma is a rare and aggressive gynecologic cancer.
• Common sites for uterine leiomyosarcoma metastasis include the lungs, bones, and brain.
• Cardiac metastasis from uterine leiomyosarcoma is exceptionally uncommon.

Observation:

• A 57-year-old female, with a history of uterine leiomyosarcoma treated 10 years prior, presented with dyspnea, dizziness, fever, and tachycardia.
• Cardiac imaging revealed interventricular septum metastasis.
• The patient also had extensive systemic metastases and a recurrent pelvic mass.

Findings:

• The patient's symptoms were attributed to widespread metastatic disease, including cardiac involvement.
• The interventricular septum was identified as a site of metastasis.
• Recurrent pelvic mass and systemic metastases were also diagnosed.

Implications:

• This case underscores the importance of considering rare metastatic sites in patients with a history of uterine leiomyosarcoma.
• Early recognition and management of cardiac metastasis are crucial for patient outcomes.
• Palliative radiotherapy and chemotherapy demonstrated a positive response in managing symptoms and disease progression.