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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Nasal T cell lymphoma: a rare entity.

Maliha Kazi1, Mubasher Ikram1, Montasir Junaid2

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Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|April 11, 2014
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Nasal type of Natural Killer (NK)/T cell lymphoma, often linked to Epstein-Barr Virus (EBV), presents unique diagnostic and prognostic challenges. Effective chemo-radiotherapy offers a promising treatment outcome for this rare cancer.

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Area of Science:

  • Oncology
  • Pathology
  • Virology

Background:

  • Nasal type of Natural Killer (NK)/T cell lymphoma is a rare malignancy predominantly affecting the nasal cavity.
  • This lymphoma subtype shows a strong association with Epstein-Barr Virus (EBV), particularly in Asian populations.

Observation:

  • The condition presents with localized and systemic symptoms, but histological confirmation is crucial for diagnosis.
  • A 35-year-old male patient presented with an ulcerative nasal lesion indicative of this lymphoma.

Findings:

  • Histological examination confirmed nasal type NK/T cell lymphoma, establishing the EBV association.
  • The patient received chemo-radiotherapy, resulting in complete symptom resolution and disease remission at six months follow-up.

Implications:

  • This case highlights the importance of histological criteria in diagnosing EBV-associated nasal NK/T cell lymphoma.
  • Successful chemo-radiotherapy management offers a positive outlook, improving survival rates for this challenging malignancy.