Related Experiment Video

Updated: May 1, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
06:00

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Published on: May 14, 2016

10.8K

TPX2 regulates tumor growth in human cervical carcinoma cells

Peiyue Jiang1, Kexin Shen2, Xuerui Wang3

  • 1Department of Gynecological Oncology, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

Molecular Medicine Reports
|April 11, 2014
PubMed

Insights

Targeting protein for Xenopus kinesin-like protein 2 (TPX2) is overexpressed in cervical cancer. Inhibiting TPX2 suppressed tumor growth, proliferation, and invasion, suggesting TPX2 as a potential therapeutic target for cervical cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Targeting protein for Xenopus kinesin-like protein 2 (TPX2) is a microtubule-associated protein.
  • Abnormal TPX2 expression is linked to various cancers, but its role in cervical cancer is unclear.

Purpose of the Study:

  • To investigate the association between TPX2 expression and the biological behavior of cervical cancer.
  • To evaluate TPX2 as a potential therapeutic target for cervical cancer.

Main Methods:

  • Immunohistochemistry and RT-PCR were used to detect TPX2 expression in cervical cancer tissues.
  • TPX2-siRNA was used to inhibit TPX2 in SiHa human cervical carcinoma cells in vitro and in vivo xenograft models.

Main Results:

  • TPX2 expression was significantly higher in cervical carcinoma tissues than in normal tissues.
  • TPX2 siRNA transfection induced apoptosis, inhibited proliferation and invasion of SiHa cells.
  • In vivo, TPX2 siRNA transfection significantly reduced tumor growth in xenograft models.

Conclusions:

  • TPX2 plays a crucial role in regulating tumor growth in cervical cancer.
  • TPX2 represents a potential therapeutic target for novel cervical cancer treatment strategies.

More Related Videos

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma06:08

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

2.6K
Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors08:45

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

5.7K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.0K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.3K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.6K