Related Experiment Video

Updated: May 1, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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An uncommon cause of acquired osteosclerosis in adults: hepatitis C-associated osteosclerosis

Narendranath Epperla1, Fergus E McKiernan

  • 1Department of Internal Medicine, Marshfield Clinic, 1000 N. Oak Ave, Marshfield, WI, 54449, USA, enaren10@gmail.com.

Skeletal Radiology
|April 11, 2014
PubMed

Insights

Hepatitis C-associated osteosclerosis (HCAO) is a rare bone disorder causing severe pain. Awareness is crucial for clinicians managing patients at risk for Hepatitis C Virus (HCV) infection.

Area of Science:

  • Bone Biology
  • Hepatology
  • Radiology

Background:

  • Hepatitis C-associated osteosclerosis (HCAO) is a rare condition.
  • It presents with debilitating bone pain, increased bone turnover, and excess bone tissue.

Observation:

  • This report details the 19th documented case of HCAO.
  • Clinical presentation and imaging findings are presented.

Findings:

  • HCAO is characterized by generalized increase in bone tissue.
  • Bone pain predominantly affects the lower extremities.

Implications:

  • Increased awareness of HCAO is vital for clinicians, especially those treating patients at risk for Hepatitis C Virus (HCV) infection.
  • Understanding HCAO's pathogenesis may offer new therapeutic targets for osteoporosis.

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