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Related Experiment Videos

Endogenous opioids and immune responses: an experimental study.

P K Mediratta1, N Das, V S Gupta

  • 1Department of Pharmacology, University College of Medical Sciences, New Delhi, India.

NIDA Research Monograph
|January 1, 1988
PubMed
Summary

Endogenous opioids influence immune responses by affecting antibody production and mediator release. Naloxone, an opioid antagonist, inhibited these responses and protected against anaphylactic shock.

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Area of Science:

  • Immunology
  • Neuroscience
  • Pharmacology

Background:

  • Endogenous opioids are peptides with diverse physiological roles.
  • Their potential involvement in immune system modulation is an area of ongoing research.
  • Humoral immune responses involve antibody production and mediator release.

Purpose of the Study:

  • To investigate the role of endogenous opioids in humoral immune responses.
  • To determine the effect of opioid agonists and antagonists on immune mediators and antibody production.

Main Methods:

  • In vitro studies using rat peritoneal mast cells to measure histamine release.
  • In vivo studies assessing protection against anaphylactic shock.
  • Measurement of haemagglutination titre and IgE antibody levels.

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Main Results:

  • Opioid agonists (morphine, leu-enkephalin) enhanced antigen-induced histamine release.
  • Naloxone antagonized agonist effects and inhibited histamine release independently.
  • Naloxone protected against anaphylactic shock and reduced antibody titers (haemagglutination and IgE).

Conclusions:

  • Endogenous opioids play a role in mediating humoral immune responses.
  • Opioids appear to influence both antibody production and the release of hypersensitivity mediators.
  • Naloxone demonstrates immunomodulatory effects, impacting both antibody levels and mediator release pathways.