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Updated: Jan 26, 2026

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HIV-1 protease-substrate coevolution in nelfinavir resistance

Madhavi Kolli1, Ayşegül Ozen1, Nese Kurt-Yilmaz1

  • 1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Journal of Virology
|April 11, 2014
PubMed
Summary

HIV-1 protease mutations cause drug resistance. Coevolving Gag cleavage sites with protease mutations help the virus maintain function, restoring substrate recognition and cleavage despite drug resistance.

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