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Updated: May 1, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
Published on: May 8, 2013
Comparison of commercial antimicrobial susceptibility test methods for testing of Staphylococcus aureus and
Stefan Riedel1, Kar Mun Neoh2, Stephen W Eisinger2
1The Johns Hopkins University, School of Medicine, Department of Pathology, Division of Microbiology, Baltimore, Maryland, USA Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA sriedel2@jhmi.edu.
Abstract:
Three commercial antimicrobial susceptibility testing (AST) methods were compared to broth microdilution for testing of Staphylococcus aureus and enterococci against vancomycin, daptomycin, and linezolid. Despite high levels of categorical agreement and essential agreement, vancomycin MICs determined by MicroScan were often 1 log2 concentration higher and MICs determined by Phoenix 1 log2 concentration lower. Daptomycin MICs were 1 to 2 log2 concentrations higher by all AST methods, except Etest, potentially impacting definitive antimicrobial therapy for bloodstream infections due to these organisms.
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