Cutting edge: The transcription factor Bob1 counteracts B cell activation and regulates miR-146a in B cells
John M Lindner1, Hiroyuki Kayo, Sebastian Hedlund
1Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany;
Abstract:
Mice lacking the lymphocyte-specific transcription factor Bob1 (also called OBF-1 or OCA-B) fail to generate germinal centers and a robust Ig response. We show that peripheral B cells in Bob1(-/-) mice bear characteristics of chronically activated or anergic-like B cells and identify the immunosuppressive microRNA-146a, together with other microRNAs, as novel transcriptional targets of Bob1. The inability to restrict B cell signaling could contribute to the immunodeficient phenotype of these mice and is consistent with an important role for Bob1 in suppressing B cell activation in vivo.
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