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Evaluating effects of deferoxamine in a rat tibia critical bone defect model
Bikramjit S Grewal1, Benjamin Keller2, Paul Weinhold3
1Department of Orthopaedics, University of North Carolina Hospitals, NC 27514, USA.
Objectives:
Evaluate the use of deferoxamine in a calcium sulfate carrier to promote fracture healing in a critical bone defect model.
Methods:
43 female retired breeders were divided randomly into Control, Carrier, DFO and BMP groups and appropriate agents placed at the osteotomy site.
Results:
There was a significant difference in the mean gap between groups Control vs DFO and Control vs BMP. A higher mean number of cortices were bridged in the DFO group as compared to the Control group.
Conclusions:
Our study demonstrated that DFO helped reduce the gap in this critical tibia defect.
