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Updated: May 1, 2026

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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[Rate and clinical characteristics of mumps reinfection]

Akio Hatanaka, Yumiko Tateishi, Keiji Honda

    Nihon Jibiinkoka Gakkai Kaiho
    |April 12, 2014
    PubMed

    Insights

    Mumps reinfection is more common than previously thought, with specific antibody levels helping to identify it. This study found mumps reinfection frequently occurs in adults with salivary gland swelling.

    Area of Science:

    • Virology
    • Immunology
    • Epidemiology

    Context:

    • Mumps infection was historically considered a once-in-a-lifetime event.
    • Recent observations suggest mumps reinfection is not rare, particularly in pediatric cases.
    • Established serological criteria aid in diagnosing mumps reinfection.

    Purpose:

    • To investigate the prevalence of mumps reinfection in adults presenting with acute salivary gland swelling.
    • To apply established diagnostic criteria for mumps reinfection in a clinical setting.

    Summary:

    • A survey conducted at Tsuchiura Kyodo General hospital from July 2010 to June 2011 enrolled 45 patients with acute major salivary gland swelling.
    • Serum IgG and IgM antibodies against the mumps virus were measured.
    • Ten cases of primary mumps infection and ten cases of mumps reinfection were identified based on specific antibody level criteria (IgG >25.8 IU/dl and IgM <2.0 IU/dl).

    Impact:

    • The study suggests mumps reinfection is a common occurrence in adults experiencing acute major salivary gland swelling.
    • Highlights the need to consider reinfection in differential diagnoses for such symptoms.
    • Contributes to a better understanding of mumps epidemiology in adult populations.

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