Related Experiment Video
Updated: May 1, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
The impact of multiplex genetic testing on disease risk perceptions
S Shiloh1, H D deHeer, S Peleg
1School of Psychological Sciences, Tel Aviv University, Tel Aviv, Israel.
Multiplex genetic testing did not significantly alter disease risk perceptions in healthy adults. Individuals cautiously interpreted results, aligning perceptions with baseline data, family history, and genetic beliefs.
Area of Science:
- Genetics
- Psychology
- Public Health
Background:
- Multiplex genetic testing offers insights into susceptibility for multiple common diseases.
- Understanding the impact of such testing on individual risk perception is crucial for public health communication.
Purpose of the Study:
- To evaluate how multiplex genetic testing affects disease risk perceptions in healthy adults.
- To identify factors influencing changes in risk perception post-testing.
Main Methods:
- A cohort of 216 healthy adults (aged 25-40) underwent multiplex genetic testing for eight common diseases.
- Baseline and follow-up surveys assessed risk perceptions and beliefs about genetic causation.
- Risk perceptions were measured before testing and three months after receiving results.
Main Results:
- Mean risk perceptions remained largely stable between baseline and follow-up.
- Baseline risk perceptions and family history were the strongest predictors of follow-up perceptions.
- Individual risk perception changes generally correlated with genetic risk markers, family history, and beliefs about genetic causality.
Conclusions:
- Healthy adults approach multiplex genetic testing results with vigilance.
- Multiplex genetic testing does not appear to cause widespread inflation of disease risk perceptions.
- Findings suggest a balanced interpretation of genetic risk information in the general population.
More Related Videos
08:15gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
Published on: October 6, 2014
07:15Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
Related Concept Videos
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenomics: Identification of New Drug Targets
Pharmacogenetics and Pharmacogenomics: Overview
Principles of Pharmacogenetics: Types of Genetic Variants
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...