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Updated: May 1, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Atopic dermatitis - all you can do from the outside.

C Gelmetti1, A Wollenberg

  • 1Department of Pathophysiology and Transplantation, Ospedale Maggiore Policlinico di Milano, Via Pace, 9, Milan, 20122, Italy.

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|April 12, 2014
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Summary
This summary is machine-generated.

Managing atopic dermatitis (AD) requires addressing both skin barrier and immune issues. Proactive therapy, alongside reactive treatments like topical corticosteroids, empowers patients and improves disease control by targeting nonlesional skin.

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Area of Science:

  • Dermatology
  • Immunology
  • Epidermal Biology

Background:

  • Atopic dermatitis (AD) involves epidermal barrier dysfunction and immune system dysregulation.
  • Current primary topical therapy for AD includes skin cleansing with emollients and moisturizers.
  • Inflamed skin in AD patients poorly tolerates direct emollient application, necessitating effective flare management.

Purpose of the Study:

  • To outline effective management strategies for atopic dermatitis.
  • To compare reactive therapy with proactive therapy for AD.
  • To highlight the immunological basis and patient-centered advantages of proactive AD management.

Main Methods:

  • Review of current therapeutic approaches for atopic dermatitis.
  • Discussion of reactive treatments including topical corticosteroids (TCS) and topical calcineurin inhibitors (TCI).
  • Explanation of proactive therapy principles, targeting nonlesional skin in AD patients.

Main Results:

  • Reactive therapy effectively manages AD flares using TCS and/or TCI.
  • Proactive therapy offers an evidence-based, immunologically founded approach for managing AD.
  • Proactive therapy enhances patient control and involvement in disease management.

Conclusions:

  • Effective atopic dermatitis management necessitates addressing both epidermal and immune components.
  • Proactive therapy represents an advanced strategy for controlling AD by treating subclinical inflammation.
  • Patient empowerment and avoidance of irritants are key components of comprehensive AD care.