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[Early maternal deprivation decreases the immunological function of F1 generation offspring in mice]
Fei Xiao1, Chaoyang Liu2, Tao Zhang1
1School of Basic Medicine, Jiamusi University, Jiamusi 154007, China.
Objective:
To explore the changes of immunological function in F1 generation offspring after suffering early maternal deprivation.
Methods:
Using Wistar rats, the maternal deprivation models were established according to our previous study. Their F1 generation offspring were enrolled for this study. The mass and indexes of spleen and thymus were measured. The phagocytosis assay was used to detect the phagocytic function of peritoneal macrophages. The proliferation of T lymphocytes was detected by MTT assay. ELISA was employed to determine the IL-2 level in serum.
Results:
The maternal deprivation decreased the mass and indexes of spleen and thymus of their offspring. The phagocytic function of macrophage, proliferation of T lymphocytes and IL-2 level in serum of F1 generation offspring were also reduced.
Conclusion:
The immunological function declines in F1 generation offspring after suffering early maternal deprivation in mice.
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