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The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
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Multicriteria decision analysis methods with 1000Minds for developing systemic sclerosis classification criteria.

Sindhu R Johnson1, Raymond P Naden2, Jaap Fransen3

  • 1Division of Rheumatology, Department of Medicine, Toronto Western Hospital, University of Toronto, Ground Floor, East Wing, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8; Division of Rheumatology, Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.

Journal of Clinical Epidemiology
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Summary
This summary is machine-generated.

Developing new classification criteria for systemic sclerosis (SSc) involved creating a sensible instrument and using forced-choice methods to reduce and weight criteria, improving expert agreement. This approach sets a standard for future classification development.

Keywords:
Classification criteriaConjoint analysisDecision analysisForced-choiceSclerodermaSensibilitySystemic sclerosis

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Area of Science:

  • Rheumatology
  • Medical Informatics
  • Clinical Epidemiology

Background:

  • Systemic sclerosis (SSc) classification criteria are evolving.
  • A need exists for a standardized instrument to collect case data for classification development.
  • Expert consensus and rigorous methodology are crucial for reliable classification criteria.

Purpose of the Study:

  • To develop and evaluate a sensible instrument for collating case data for SSc classification.
  • To reduce and weight classification criteria using forced-choice methods.
  • To assess expert agreement on SSc classification probabilities.

Main Methods:

  • A standardized instrument was tested for sensibility with 20 SSc cases.
  • Experts used forced-choice methods to rank, reduce, and weight criteria.
  • Intraclass correlation coefficients (ICCs) evaluated consistency in expert rankings.

Main Results:

  • The instrument demonstrated high face and content validity, clarity, and comprehensibility.
  • Key criteria were weighted, including friction rubs (21 points) and fingertip lesions (9-21 points).
  • Initial expert agreement (ICC) was 0.73, improving to 0.80 after applying the methods.

Conclusions:

  • A 39% reduction in criteria was achieved using a sensible instrument and forced-choice methods.
  • The developed methods offer a rigorous, measurement-science-based template for creating classification criteria.
  • This study provides a robust framework for future SSc classification development.