Related Experiment Video

Updated: May 1, 2026

Visualization of Replisome Encounters with an Antigen Tagged Blocking Lesion
08:24

Visualization of Replisome Encounters with an Antigen Tagged Blocking Lesion

Published on: July 27, 2021

1.3K

When PRRs collide: mincle meddles with dectin and toll

Amariliz Rivera1

  • 1Department of Pediatrics, Center for Immunity and Inflammation, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07101, USA.

Cell Host & Microbe
|April 12, 2014
PubMed

Insights

Pattern recognition receptors (PRRs) can oppose each other. Fungal Mincle signaling suppresses interleukin-12 (IL-12) transcription, weakening the immune system

Area of Science:

  • Immunology
  • Microbiology
  • Cellular Biology

Background:

  • Pattern recognition receptors (PRRs) are crucial for pathogen detection and adaptive immunity.
  • Interactions between different PRRs are known to influence immune responses.
  • The specific mechanisms by which PRRs antagonize each other remain largely unexplored.

Purpose of the Study:

  • To elucidate a mechanism of PRR antagonism in the context of fungal infections.
  • To investigate how Mincle signaling impacts the immune response to fungal pathogens.
  • To understand the regulation of interleukin-12 (IL-12) transcription by PRRs.

Main Methods:

  • Utilized fungal components to induce Mincle signaling in immune cells.
  • Assessed the transcriptional levels of IL-12 under different PRR activation conditions.
  • Investigated the downstream effects of Mincle-mediated suppression on antifungal immunity.

Main Results:

  • Fungal-induced Mincle signaling was found to suppress IL-12 transcription.
  • This suppression occurred independently of other PRR-mediated signaling pathways.
  • The inhibition of IL-12 production by Mincle signaling resulted in abated antifungal immunity.

Conclusions:

  • A novel mechanism of PRR antagonism has been identified, involving Mincle signaling.
  • Mincle-mediated suppression of IL-12 transcription is a key factor in regulating antifungal immune responses.
  • Understanding this antagonism is critical for developing strategies to enhance antifungal immunity.

More Related Videos

Super-Resolution Imaging to Study Co-Localization of Proteins and Synaptic Markers in Primary Neurons14:02

Super-Resolution Imaging to Study Co-Localization of Proteins and Synaptic Markers in Primary Neurons

Published on: October 31, 2020

5.3K
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

7.1K

Related Concept Videos

Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart,...
5.1K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
6.2K
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
1.3K
Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
870
Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...
3.1K
¹H NMR: Complex Splitting01:13

¹H NMR: Complex Splitting

A proton M that is coupled to a proton X results in doublet signals for M. However, NMR-active nuclei can be simultaneously coupled to more than one nonequivalent nucleus. When M is coupled to a second proton A, such as in styrene oxide, each peak in the doublet is split into another doublet.
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied...
1.7K