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Viscoelastic parameters for quantifying liver fibrosis: three-dimensional multifrequency MR elastography study on
Maxime Ronot1, Simon A Lambert2, Mathilde Wagner1
1Department of Radiology, Beaujon University Hospitals Paris Nord Val de Seine, Clichy, France; University Paris Diderot, Sorbonne Paris Cité, France; IPMA, INSERM U773, Centre de Recherche Biomédicale Bichat-Beaujon, Paris, France.
Plos One
|April 12, 2014
Summary
The storage modulus in multifrequency MR elastography best quantifies liver fibrosis severity in rats. Its diagnostic performance is comparable to the complex shear modulus for assessing liver fibrosis.
Area of Science:
- Biomedical Engineering
- Radiology
- Hepatology
Background:
- Liver fibrosis assessment is crucial for managing chronic liver diseases.
- Non-invasive imaging techniques are needed to accurately quantify fibrosis.
- Magnetic Resonance Elastography (MRE) shows promise for liver fibrosis evaluation.
Purpose of the Study:
- To determine the best viscoelastic parameter for quantifying liver fibrosis using high-resolution, three-dimensional multifrequency MR elastography.
- To compare the diagnostic performance of different viscoelastic parameters in a rat model.
Main Methods:
- High-resolution, 3D multifrequency MRE was performed on rat liver slices at 7T.
- Mechanical frequencies of 500, 600, and 700 Hz were applied.
- Viscoelastic parameters (complex shear, storage, loss moduli) were calculated and correlated with histopathological fibrosis scores.
Main Results:
- The storage modulus at 600 Hz showed the strongest association with fibrosis severity (r=0.86, p<0.0001).
- The storage modulus achieved an Obuchowski measure of 0.89±0.03.
- Its diagnostic performance was significantly better than the loss modulus but comparable to the complex shear modulus.
Conclusions:
- The storage modulus is the most effective viscoelastic parameter for quantifying liver fibrosis severity using 3D multifrequency MRE in thin liver slices.
- Diagnostic performance of storage modulus is similar to complex shear modulus, suggesting potential for clinical application.
