Related Experiment Video
Updated: May 1, 2026
Retinal Pathophysiological Evaluation in a Rat Model
Published on: May 6, 2022
Retinal profile: a clinical indicator of severity in dengue fever in a suburban Indian environment
Rubii Malhotra1, Luxmi Singh2, R K Bundela3
1Associate Professor, Ophthalmology Department, Era's Lucknow Medical College & Hospital, Lucknow, India docrubie@hotmail.com.
Purpose:
To study the retinal changes in subjects suffering from dengue fever and check if these changes can be taken as sufficient indicator of severity and progression of the disease.
Patients/Methods:
A detailed history was recorded of 118 patients on whom ocular examination, including direct ophthalmoscopy, indirect ophthalmoscopy and coloured fundus photography, was performed.
Results:
Forty-seven percent of patients were found to have posterior segment abnormalities. Retinal vein dilatation or tortuosity was the most common finding followed by changes in the optic disc (8.4% of patients) and background haemorrhage (6.7% of patients). With increasing severity of thrombocytopenia, the proportion of patients with retinal abnormalities increased. In patients with grade I thrombocytopenia, no fundal abnormality was found. In those with grade II thrombocytopenia, fundal abnormality was found in 13.63% patients, whereas in the grade III category it was 27.90%.
Conclusions:
Severity of thrombocytopenia had a significant association with retinal abnormalities. Occurrence of fundus changes increases with an increase in severity of thrombocytopenia. Fundus changes were found in all patients with grade IV thrombocytopenia.
