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Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC Crosslinking of Small Molecules to Isolate Chromatin
Published on: January 20, 2016
Evaluation of DNA binding with some selected hydrazide and semicarbazide derivatives
Sannapaneni Janardan1, Pothini Suman, G Swapna
1Department of Chemistry, School of Advanced Sciences, VIT University, Vellore, 632 014, Tamil Nadu, India.
Abstract:
A group of hydrazide and semicarbazide derivatives containing isopropylidene, benzylidene, cyclohexylidene, and phospholidene groups was synthesized and characterized by spectroscopic techniques. These compounds were tested for DNA interaction studies monitored by UV-Vis and IR data as well as molecular docking. Investigations on interactions of these compounds with DNA revealed an intercalative mode of binding between them. It is interesting to note that semicarbazide derivatives with aliphatic substituents showed better DNA binding than the aromatic substituents.
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