Associations between rs965513/rs944289 and papillary thyroid carcinoma risk: a meta-analysis

Single-nucleotide polymorphisms of rs965513 (9q22.33) and rs944289 (14q13.3) may be involved in the pathogenesis of papillary thyroid carcinoma (PTC). But, relevant genetic studies reported different results. The aim of this meta-analysis was to derive a more precise assessment of the association of rs965513/rs944289 polymorphism with PTC risk. Relevant studies were identified using PubMed, ISI Web of knowledge, Medline, Embase, Google Scholar Search database, SinoMed (Chinese), CNKI (Chinese), GeNii (Japanese) and ICHUSHI (Japanese) (update to December, 2013). A total of eight case-control studies with 52,363 subjects for rs965513 and 51,120 subjects for rs944289 were included. The results showed significant associations of rs965513/rs944289 with PTC risk existed in overall population (for rs965513, A vs. G: OR 1.71 (1.56-1.86); for rs944289, T vs. C: OR 1.29 (1.23-1.37)). Subgroup analysis by ethnicity showed that there were significant associations in Asians (for rs965513, A vs. G: OR 1.48 (1.27-1.73); for rs944289, T vs. C: OR 1.35 (1.18-1.55)), in Europeans (for rs965513, A vs. G: OR 1.74 (1.61-1.88); for rs944289, T vs. C: OR 1.24 (1.14-1.34)), and in Americans (for rs965513, A vs. G: OR 2.00 (1.76-2.27); for rs944289, T vs. C: OR 1.29 (1.14-1.47)). In conclusion, Rs965513 [A] and rs944289 [T] are risk factors of PTC. Effect estimate for rs965513 polymorphism is higher in Americans than in Asians.