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Related Concept Videos

Resistance and Conductance01:25

Resistance and Conductance

730
A conductor's DC resistance at a given temperature is influenced by its resistivity, length, and cross-sectional area. Resistivity is an inherent property of the conductor material, with annealed copper serving as the international standard for measurement. For instance, the resistivity of hard-drawn aluminum at 20 degrees Celsius is 61% of the standard conductivity of annealed copper.
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
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Equivalent Resistance01:16

Equivalent Resistance

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In circuit analysis, situations often arise where resistors are neither in series nor parallel configurations. To tackle such scenarios, three-terminal equivalent networks like the wye (Y) (Figure 1 (a)) or tee (T) and delta (Δ) (Figure 1 (b)) or pi (π) networks come into play. These networks offer versatile solutions and are frequently encountered in various applications, including three-phase electrical systems, electrical filters, and matching networks.
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Resistors In Parallel01:23

Resistors In Parallel

5.8K
Resistors are in parallel when one end of all the resistors are connected to a continuous wire of negligible resistance and the other end of all the resistors are also connected to one another through a continuous wire of negligible resistance. In the case of a parallel configuration, the potential drop across each resistor is the same. Current through each resistor can be found using Ohm’s law, I = V/R, where the voltage is constant across each resistor. The sum of the individual...
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Resistors In Series01:10

Resistors In Series

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A resistor is an ohmic device that limits the flow of charge in a circuit. Most circuits have more than one resistor. If several resistors are connected together and connected to a battery, the current supplied by the battery depends on the equivalent resistance of the circuit. The equivalent resistance of a combination of resistors depends on both their individual values and how they are connected. The simplest combination of resistors is the series combination.
In a series circuit, the...
5.9K
Resistance01:19

Resistance

6.8K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.8K
Bode Plots Construction01:24

Bode Plots Construction

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The Bode plot is an essential tool in control system analysis, mapping the frequency response of a system through a magnitude plot and a phase plot, both against a logarithmic frequency axis. To construct a Bode plot, consider the transfer function H(ω):
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Related Experiment Video

Updated: May 1, 2026

Human iPSC-Derived Cardiomyocyte Networks on Multiwell Micro-electrode Arrays for Recurrent Action Potential Recordings
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Human iPSC-Derived Cardiomyocyte Networks on Multiwell Micro-electrode Arrays for Recurrent Action Potential Recordings

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FV and APC resistance: the plot thickens.

Elisabetta Castoldi1

  • 1MAASTRICHT UNIVERSITY.

Blood
|April 12, 2014
PubMed
Summary

A novel factor V gene mutation (FVNara) was identified in a Japanese patient with severe thrombosis, linked to activated protein C resistance. This finding offers new insights into the molecular basis of APC resistance.

Area of Science:

  • Hematology
  • Molecular Biology
  • Genetics

Background:

  • Activated protein C (APC) resistance is a major risk factor for venous thromboembolism.
  • The factor V (FV) gene is a common site for mutations causing APC resistance, typically near APC cleavage sites.

Purpose of the Study:

  • To report a novel factor V gene mutation associated with APC resistance and a severe thrombotic phenotype.
  • To investigate the molecular mechanisms underlying APC resistance caused by mutations distant from known cleavage sites.

Main Methods:

  • Genetic sequencing of the factor V gene in a patient with severe thrombosis.
  • Analysis of the mutation's location and potential impact on FV protein structure and function.

Main Results:

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  • Identification of a novel FV gene mutation, FVNara (Trp1920→Arg).
  • The FVNara mutation is associated with APC resistance and a severe thrombotic phenotype.
  • The affected residue is in the FV light chain, far from established APC cleavage sites.

Conclusions:

  • The FVNara mutation represents a new cause of APC resistance.
  • This discovery expands our understanding of the molecular mechanisms of APC resistance.
  • FV mutations distant from cleavage sites can contribute to thrombotic risk.