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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

160
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Biosynthesis of Polysaccharides01:26

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Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
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High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
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Polysaccharide nanosystems for future progress in cardiovascular pathologies.

Amanda Karine Andriola Silva1, Didier Letourneur1, Cédric Chauvierre1

  • 1Inserm, U698, Cardiovascular Bio-Engineering; X. Bichat hospital, 46 rue H. Huchard, F-75018, Paris, France; Université Paris 13, Sorbonne Paris Cité, F-93430, Villetaneuse, France.

Theranostics
|April 12, 2014
PubMed
Summary
This summary is machine-generated.

Natural polysaccharides are versatile biomaterials for creating advanced nanosystems. These polysaccharide-based nanosystems offer potential for targeted drug delivery and molecular imaging in treating cardiovascular diseases.

Keywords:
AtherothrombosisDrug deliveryMolecular imaging.NanosystemsPolysaccharides

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Natural polysaccharides from diverse renewable sources (plants, bacteria, fungi, algae) are gaining attention in biomedicine.
  • Advances in polysaccharide chemistry and nanotechnology enable the creation of novel polysaccharide-based nanosystems.
  • Atherothrombotic diseases are a leading cause of mortality, highlighting the need for effective treatments and diagnostic tools.

Purpose of the Study:

  • To provide an overview of polysaccharide-based nanosystems.
  • To highlight their application as drug delivery systems.
  • To discuss their use as targeted contrast agents for molecular imaging, particularly for cardiovascular pathologies.

Main Methods:

  • Review of current literature on polysaccharide chemistry and nanotechnology.
  • Analysis of polysaccharide-based nanosystems for drug delivery applications.
  • Evaluation of polysaccharide-based nanosystems for molecular imaging and contrast agent development.

Main Results:

  • Polysaccharide-based nanosystems can be engineered for specific biological interactions.
  • These nanosystems show promise for targeted drug delivery to affected tissues.
  • Polysaccharide-nanoparticles can function as targeted contrast agents for enhanced molecular imaging.

Conclusions:

  • Polysaccharide-based nanosystems represent a promising platform for advanced biomedical applications.
  • Their application in cardiovascular disease treatment and imaging warrants further investigation.
  • The versatility and renewable nature of polysaccharides make them attractive for developing next-generation nanomedicines.