Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

20
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
20
Fatigue01:21

Fatigue

1.1K
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
1.1K
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

4.4K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.4K
Dementia l: Introduction01:22

Dementia l: Introduction

35
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
35
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

53
The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
53
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

3.3K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modulation of the immunological and neuroinflammatory microenvironment in older people with multiple sclerosis.

Frontiers in immunology·2026
Same author

Efficacy and Safety of Patients With Relapsing Multiple Sclerosis Switching to Ocrelizumab Due to Suboptimal Treatment Response: Results of the 4-Year CASTING-LIBERTO Trial.

European journal of neurology·2026
Same author

Validation and psychometric properties of the Multiple Sclerosis Autonomy Score (MSAS) in a French cohort: The FOCAL-MS 2 study.

Multiple sclerosis and related disorders·2026
Same author

Progression to Wheelchair in Secondary Progressive Multiple Sclerosis and Impact of Siponimod: Post Hoc Analyses From the EXPAND Study.

European journal of neurology·2026
Same author

A Qualitative Study of Lived Treatment Experiences and Preferences of Long-Term DMT Users with Relapsing-Remitting Multiple Sclerosis.

Neurology and therapy·2026
Same author

A predictive tool for early treatment escalation after initiation of moderate-efficacy therapy in pediatric-onset multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026

Related Experiment Video

Updated: May 1, 2026

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

5.4K

Does fatigue complaint reflect memory impairment in multiple sclerosis?

Caroline Jougleux-Vie1, Emeline Duhin1, Valerie Deken2

  • 1Department of Neurology, Roger Salengro Hospital, 59037 Lille, France.

Multiple Sclerosis International
|April 12, 2014
PubMed
Summary
This summary is machine-generated.

In multiple sclerosis (MS), fatigue complaints do not reflect objective memory impairment. However, subjective fatigue in MS patients is linked to memory complaints, not actual memory deficits.

More Related Videos

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
05:38

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

731
The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

18.8K

Related Experiment Videos

Last Updated: May 1, 2026

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

5.4K
The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
05:38

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model

Published on: April 12, 2024

731
The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

18.8K

Area of Science:

  • Neurology
  • Neuropsychology

Background:

  • Fatigue and memory impairment are prevalent symptoms in multiple sclerosis (MS).
  • These symptoms can interact with cognition, potentially misrepresenting the severity of the neurological disorder.
  • Understanding the relationship between subjective complaints and objective deficits is crucial for accurate patient assessment.

Purpose of the Study:

  • To investigate if fatigue complaints in MS patients correlate with objective memory impairment.
  • To determine the association between subjective fatigue and memory complaints in MS.
  • To clarify whether subjective fatigue reflects actual memory deficits in multiple sclerosis.

Main Methods:

  • Fifty MS patients with fatigue complaints underwent subjective assessments for fatigue and memory.
  • Cognitive function, specifically verbal episodic memory, was evaluated using the Selective Reminding Test (SRT).
  • Statistical analyses explored correlations between subjective reports and objective test performance, controlling for confounding factors like depression and disability.

Main Results:

  • After adjusting for confounding factors (depression, medication, EDSS, MS form), fatigue complaints did not correlate with SRT performance.
  • Similarly, memory complaints were not correlated with objective verbal episodic memory performance.
  • A significant association was found between subjective fatigue and memory complaints.

Conclusions:

  • Subjective fatigue complaints in MS are associated with memory complaints.
  • However, subjective fatigue does not appear to be a direct manifestation of objective memory impairment in multiple sclerosis.
  • These findings highlight the complexity of symptom reporting in MS and the need to differentiate subjective experiences from objective cognitive deficits.