Non-syndromic multiple odontogenic keratocyst: a case report

Area of Science:

• Oral and Maxillofacial Surgery
• Dermatology
• Genetics

Background:

• Odontogenic keratocyst (OKC) is a prevalent developmental cyst in the maxillofacial region.
• Multiple OKCs are frequently associated with Nevoid Basal Cell Carcinoma Syndrome (NBCCS).
• However, a subset of patients presents with multiple OKCs without syndromic features.

Observation:

• This report details a clinical case.
• The patient presented with multiple odontogenic keratocysts.
• The patient did not exhibit signs of Nevoid Basal Cell Carcinoma Syndrome.

Findings:

• The case confirms the occurrence of multiple OKCs in a non-syndromic individual.
• This presentation deviates from the typical association with NBCCS.
• It underscores the importance of considering isolated multiple OKCs.

Implications:

• This case broadens the differential diagnosis for multiple OKC presentations.
• It suggests that genetic or developmental factors independent of NBCCS may lead to multiple OKCs.
• Further research may elucidate the specific mechanisms underlying non-syndromic multiple OKC development.