High-resolution melting assay for genotyping of IFNL4-associated dinucleotide variant rs368234815
E Galmozzi1, F Facchetti, R Perbellini
1Division of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.
Abstract:
Interferon-λ4-related dinucleotide variant rs368234815 TT/-G is strongly linked with rs12979860 polymorphism, the most important genetic marker connected to treatment-induced hepatitis C virus clearance. Due to additional baseline information that rs368234815 polymorphism could provide for the management of chronic hepatitis C, we developed and validated a high-resolution melting genotyping assay using 193 patients with chronic hepatitis C.
