Related Experiment Video

Updated: May 1, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

12.2K

Gene delivery for cancer therapy

Teng Zhang1

  • 1College of Computer, Mathematical, & Natural Sciences, University of Maryland, 2300 Symons Hall, College Park, MD 20742, United States. zhangt682@gmail.com.

Current Drug Delivery
|April 15, 2014
PubMed

Insights

Gene therapy shows promise for cancer treatment, but efficient gene delivery systems are crucial for success. This review examines current gene delivery methods, their limitations, and future directions for effective cancer gene therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biotechnology

Background:

  • Gene therapy offers potential for treating human cancers.
  • Clinical success is limited by inefficient gene delivery systems.
  • High-efficiency transduction for therapeutic transgene expression remains a challenge.

Purpose of the Study:

  • To review available gene delivery systems for cancer gene therapy.
  • To outline the characteristics, utilities, advantages, and drawbacks of these systems.
  • To discuss existing challenges and future research directions.

Main Methods:

  • Literature review of gene delivery systems.
  • Analysis of transduction efficiencies and transgene expression levels.
  • Evaluation of system suitability for cancer treatment.

Main Results:

  • Various gene delivery systems possess distinct characteristics.
  • Current systems face limitations in achieving high transduction efficiencies.
  • No single system is universally optimal for all cancer gene therapy applications.

Conclusions:

  • Efficient gene delivery is paramount for successful cancer gene therapy.
  • Further development is needed to overcome current challenges.
  • Future research should focus on improving delivery systems for enhanced therapeutic outcomes.

More Related Videos

Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles08:35

Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles

Published on: January 4, 2012

28.7K
A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy09:56

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

Published on: February 21, 2025

1.5K

Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
22.1K
Gene Therapy00:59

Gene Therapy

4.5K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.4K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.3K