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Published on: August 15, 2019
Understanding genetic variation - the value of systems biology
1School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, D-28759, Bremen, Germany.
Abstract:
Pharmacology is currently transformed by the vast amounts of genome-associated information available for system-level interpretation. Here I review the potential of systems biology to facilitate this interpretation, thus paving the way for the emerging field of systems pharmacology. In particular, I will show how gene regulatory and metabolic networks can serve as a framework for interpreting high throughput data and as an interface to detailed dynamical models. In addition to the established connectivity analyses of effective networks, I suggest here to also analyze higher order architectural properties of effective networks.
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