Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

4.5K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.5K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.4K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.4K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

3.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
3.8K
Stem Cell Niche01:26

Stem Cell Niche

5.0K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Challenging Spontaneous Quantum Collapse with the XENONnT Dark Matter Detector.

Physical review letters·2026
Same author

Observation of Charmonium Sequential Suppression in Heavy-Ion Collisions at the Relativistic Heavy Ion Collider.

Physical review letters·2026
Same author

[Integrated multitask visual-guided system for nasopharyngeal carcinoma detection using nasopharyngeal endoscopy: a retrospective multicenter study].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2026
Same author

Energy Independence of the Collins Asymmetry in p^{↑}p Collisions.

Physical review letters·2026
Same author

WIMP Dark Matter Search Using a 3.1 Tonne-Year Exposure of the XENONnT Experiment.

Physical review letters·2025
Same author

[Transfer learning-based endoscopic image recognition of nasopharyngeal carcinoma: investigating pre-trained large models in small sample settings].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2025
Same journal

Authors' Reply "Synchronous Soft-Tissue Lesions in the Oral Cavity in an Adolescent".

Oral diseases·2026
Same journal

Neutrophils From Aged Individuals Release NETs to Impair Oral Wound Healing Through NLRP3 Activation.

Oral diseases·2026
Same journal

Comment on "Multimodal Deep Learning-Based Screening of Degenerative Temporomandibular Joint Disease Using 2D Radiography: A Cost-Effective and Low-Radiation Approach".

Oral diseases·2026
Same journal

Oral Lesions and Dental Status in Individuals Using Oral Tobacco-Free Nicotine Pouches.

Oral diseases·2026
Same journal

Comment on "Synchronous Soft-Tissue Lesions in the Oral Cavity in an Adolescent".

Oral diseases·2026
Same journal

Atypical Whitish Gingival Plaque.

Oral diseases·2026
See all related articles

Related Experiment Video

Updated: May 1, 2026

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs
06:20

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs

Published on: December 24, 2015

12.2K

Immunomodulation regulates mesenchymal stem cell-based bone regeneration.

Y Su1, S Shi, Y Liu

  • 1Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory for Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, China.

Oral Diseases
|April 15, 2014
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSCs) show promise for bone repair. This review explores how MSCs work in bone regeneration, focusing on their interaction with the immune system for new bone growth.

Keywords:
immune responsemesenchymal stem cellregeneration

More Related Videos

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging
09:10

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Published on: July 16, 2021

2.5K
Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases
07:45

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Published on: September 1, 2017

11.7K

Related Experiment Videos

Last Updated: May 1, 2026

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs
06:20

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs

Published on: December 24, 2015

12.2K
Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging
09:10

Mesenchymal Stem Cell Regulation of Macrophage Phagocytosis; Quantitation and Imaging

Published on: July 16, 2021

2.5K
Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases
07:45

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Published on: September 1, 2017

11.7K

Area of Science:

  • Regenerative Medicine
  • Orthopedics
  • Immunology

Background:

  • Mesenchymal stem cells (MSCs) are key in regenerative medicine for bone reconstruction.
  • Understanding MSC capacities for bone repair is crucial for clinical applications.

Purpose of the Study:

  • To summarize current knowledge on MSC mechanisms in bone regeneration.
  • To highlight the role of the host immune response in MSC-mediated bone repair.

Main Methods:

  • Literature review of studies on MSCs and bone regeneration.
  • Analysis of the interplay between donor MSCs and host immune cells.
  • Focus on mechanisms of new bone formation.

Main Results:

  • MSCs possess significant potential for bone tissue engineering.
  • The host immune response critically influences MSC behavior and efficacy.
  • Specific interactions between MSCs and immune cells modulate bone regeneration outcomes.

Conclusions:

  • MSC-based therapies offer a promising approach for bone defects.
  • Modulating the immune microenvironment can enhance MSC therapeutic potential.
  • Further research into MSC-immune cell interactions is vital for optimizing bone regeneration strategies.