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Related Experiment Video

Updated: May 1, 2026

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions

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Published on: March 8, 2019

Monocyte activity is linked with abdominal aortic aneurysm diameter.

Kiana M Samadzadeh¹, Kevin C Chun¹, Anthony T Nguyen¹

¹Department of Research, Sacramento VA Medical Center, Mather, California.

The Journal of Surgical Research

|April 15, 2014

Summary

Monocytes from abdominal aortic aneurysm (AAA) patients show increased adhesion and transmigration, correlating with AAA size. This heightened monocyte activity is linked to elevated matrix metalloproteinase-9 (MMP-9) and reduced tissue inhibitor of metalloproteinase-4 (TIMP-4).

Keywords:

Abdominal aortic aneurysm Adhesion Inflammation Matrix metalloproteinase Monocytes Transmigration

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Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Published on: October 17, 2017

Area of Science:

Cardiovascular Biology
Immunology
Vascular Medicine

Background:

Systemic inflammation and elevated matrix metalloproteinases (MMPs) contribute to abdominal aortic aneurysm (AAA) expansion by degrading elastin.
Statin therapy has shown promise in reducing AAA expansion via anti-inflammatory mechanisms.
Monocyte activity is hypothesized to be a key factor in AAA development.

Purpose of the Study:

To investigate the role of monocyte cell adhesion and transendothelial migration in abdominal aortic aneurysm (AAA) pathogenesis.
To compare monocyte activity and matrix metalloproteinase (MMP) concentrations between AAA patients and non-aneurysm controls.
To explore the relationship between monocyte behavior, AAA diameter, and specific MMP/TIMP levels.

Main Methods:

Peripheral blood monocytes were isolated from control (n=15) and AAA (n=13) patients.
Monocyte adhesion and transmigration assays were performed in vitro.
Concentrations of MMP-9 and tissue inhibitor of metalloproteinase-4 (TIMP-4) were measured in patient serum and cell culture supernatant using Luminex assays.

Main Results:

Monocytes from AAA patients exhibited significantly increased adhesion to endothelium compared to controls (P=0.005).
Monocyte transmigration across the endothelium was also significantly higher in AAA patients (P=0.01).
Both adhesive and transmigratory monocyte counts were directly proportional to AAA diameter, with elevated serum MMP-9 and decreased TIMP-4 levels observed in AAA patients.

Conclusions:

In vitro studies demonstrate enhanced monocyte adhesion and transmigration in AAA patients.
Elevated MMP-9 and diminished TIMP-4 levels are associated with increased monocyte activity in AAA.
Modulating monocyte function presents a potential therapeutic strategy for mitigating AAA expansion.