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Related Experiment Video

Updated: May 1, 2026

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Isolated right ventricular dysfunction in patients with human immunodeficiency virus.

Marc A Simon1,2, Christopher D Lacomis3, M Patricia George4

  • 1Heart and Vascular Institute, University of Pittsburgh.

Journal of Cardiac Failure
|April 15, 2014
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Summary

Right ventricular (RV) dysfunction is common in HIV patients, affecting 11% of those studied. This RV dysfunction appears distinct from pulmonary hypertension or left ventricular issues and warrants further investigation.

Keywords:
HIVPulmonary hypertensioncardiomyopathyright ventricle

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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pulmonology

Background:

  • HIV infection increases risk for pulmonary hypertension and cardiomyopathy.
  • Right ventricular (RV) dysfunction is linked to poor outcomes in these conditions.
  • Prevalence of RV dysfunction in HIV is not well-defined.

Purpose of the Study:

  • To determine the prevalence of RV dysfunction in an outpatient HIV cohort.

Main Methods:

  • Evaluated echocardiograms from 104 HIV-infected adults.
  • Measured estimated pulmonary arterial systolic pressure (PASP) and RV function metrics (TAPSE, RVLMS, RVFAC, MPI).

Main Results:

  • 11% of subjects had RV dysfunction (RVFAC <35%).
  • Elevated PASP (>35 mm Hg) was present in 15% but did not correlate with RV function.
  • RV dysfunction was not associated with left ventricular ejection fraction (LVEF) differences.

Conclusions:

  • RV dysfunction is common in HIV-infected individuals.
  • RV dysfunction may be independent of pulmonary hypertension and left ventricular dysfunction.
  • Further research is needed to understand RV dysfunction in HIV.