Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.0K
Menopause01:28

Menopause

5.0K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
5.0K
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

5.2K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
5.2K
Bone Remodeling01:40

Bone Remodeling

34.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.4K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K
Infertility in Males01:23

Infertility in Males

665
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
665

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of Serum Kappa Free Light Chain Reference Interval Using a New Stabilized Calibrator.

The journal of applied laboratory medicine·2026
Same author

A Gradual Positive Bias in Chloride Measurements with a Major Automated Chemistry Platform.

The journal of applied laboratory medicine·2025
Same author

Discordant Point-of-Care and Laboratory Hemoglobin A1c Concentrations in Ambulatory Settings.

The journal of applied laboratory medicine·2024
Same author

Consensus Considerations and Good Practice Points for Use of Continuous Glucose Monitoring Systems in Hospital Settings.

Diabetes care·2024
Same author

Monitoring tacrolimus toxicity following Paxlovid administration in a liver transplant patient.

Practical laboratory medicine·2023
Same author

Analytical Performance Evaluation of Three Point-of-Care CBC Analyzers for Management of Clozapine Therapy in Ambulatory Psychiatry Clinics.

The journal of applied laboratory medicine·2023

Related Experiment Video

Updated: May 1, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

1.6K

Osteoporosis in men.

Nichole Korpi-Steiner1, Denise Milhorn1, Catherine Hammett-Stabler1

  • 1Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA.

Clinical Biochemistry
|April 15, 2014
PubMed
Summary
This summary is machine-generated.

Osteoporosis in men is a growing public health concern. While bone mineral density scans and fracture risk assessments guide treatment, more research is needed on anti-fracture benefits for men.

Keywords:
Bone markersBone mineral densityBone remodelingBone resorptionBone turnoverFracture-riskGonadal steroid hormonesMenOsteopeniaOsteoporosis

More Related Videos

Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

23.6K
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.1K

Related Experiment Videos

Last Updated: May 1, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

1.6K
Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

23.6K
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.1K

Area of Science:

  • Gerontology
  • Orthopedics
  • Endocrinology

Background:

  • Osteoporosis in men leads to significant morbidity and mortality.
  • Aging populations exacerbate the public health challenge of male osteoporosis.
  • Recent research clarifies bone remodeling and male-specific skeletal physiology.

Purpose of the Study:

  • To review the current understanding of osteoporosis in adult men.
  • To highlight diagnostic and treatment strategies for male osteoporosis.
  • To identify gaps in knowledge regarding anti-fracture efficacy.

Main Methods:

  • Review of studies from the past decade on male bone health.
  • Focus on bone remodeling, physiology, and pathophysiology in men.
  • Evaluation of diagnostic tools like bone mineral density (BMD) and fracture risk assessment.

Main Results:

  • Dual-energy X-ray absorptiometry (DXA) is the gold standard for diagnosing osteoporosis in men.
  • Pharmacological treatments show efficacy in improving BMD and reducing resorption markers.
  • Limited data exists on the anti-fracture benefits of these treatments in men.

Conclusions:

  • Osteoporosis management in men relies on BMD and fracture risk assessment.
  • Pharmacological interventions are effective in improving bone density and turnover markers.
  • Further investigation into anti-fracture outcomes in men is crucial for comprehensive care.